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Neuropsychological functioning and brain magnetic resonance imaging(MRI) were evaluated in 84 men with adrenomyeloneuropathy(AMN).MRI was normal in 61%,the"pure AMN"group,while 39%,the"cerebral AMN"group,showed brain white matter abnormalities.Except for mild deficits in psychomotor speed and visual memory,neuropsychological function was normal in pure AMN.Most patients with cerebral AMN had normal IQ and language but evidenced impaired psychomotor speed,spatial cognition,memory,and executive functions.Patients with MRI evidence of very severe cerebral disease had global and language impairment as well,and deficits in all patients were highly correlated with degree of brain MRI involvement. |
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